CURRICULUM VITAE

Makoto AKASHI, M.D., Ph.D.

Akita

Executive Director National Institute of Radiological Sciences

PERSONAL INFORMATION

Surname: Akashi Given name: Makoto Date of birth: 29 October 1954 Birth Place: Tokyo, Japan Nationality: Japanese

Dr. Akashi was awarded his MD degree from Yamagata University School of Medicine in Yamagata Japan and his PhD from the Graduate School of Medicine, Jichi Medical School in Tochigi Japan where he also did his residencies in Internal Medicine and Hematology. He has been a research fellow at the Division of Hematology/Oncology at the University of California at Los Angeles (UCLA) School of Medicine. He has been working at the National Institute of Radiological Sciences (NIRS) in Chiba Japan since 1990 where he recently became Executive Director.

PRESENT MAILING ADDRESS

National Institute of Radiological Sciences 4-9-1 Anagawa, Inage-ku, Chiba, 263-8555, Japan.

Phone : +81-43-206-3002 (Direct Line) F a x : +81-43-256-6282 (Direct Line) E-mail : akashi@nirs.go.jp

EDUCATION

April, 1975-March, 1981 : Yamagata University, School of Medicine (Yamagata, Japan) Awarded the degree of MD

April, 1985-March, 1989: Awarded the Degree of Ph D from Graduate School of Medicine, Jichi Medical School (Tochigi, Japan)

RESEARCH AND PROFESSIONAL EXPERIENCES

May, 1981-May, 1983: Junior Resident, Department of Internal Medicine, Jichi Medical School Hospital, Tochigi, Japan.
June, 1983-April, 1985: Senior Resident, Division of Hematology, Department of Medicine, Jichi Medical School Hospital
November,1987-March, 1990: Research Fellow, Division of Hematology/Oncology, UCLA School of Medicine, Los Angeles, California
April, 1990-May, 1992: Researcher, Division of Radiation Health, National Institute of Radiological Sciences, Chiba, Japan
June, 1992-March, 1993: Senior Researcher, Division of Radiation Health, National Institute of Radiological Sciences, Chiba, Japan
April, 1993-March, 1997: Chief, Section of Hematology, Division of Radiation Health, National Institute of Radiological Sciences, Chiba, Japan
March, 1994-June, 1994: Visiting Scientist, Hematology / Oncology, Cedars-Sinai Medical Center / UCLA
April, 1997-March, 2001: Chief, Section of Clinical Hematology and Radiation Injury Control, Division of Radiation Health, National Institute of Radiological Sciences, Chiba, Japan
April, 2001- March, 2003: Chief, Section of Clinical Investigation and Medical Biology, The Research Center for Radiation Emergency Medicine, National Institute of Radiological Sciences, Chiba, Japan
April, 2003 - March, 2007: Director, The Department of Radiation Emergency Medicine, The Research Center for Radiation Emergency Medicine, National Institute of Radiological Sciences, Chiba, Japan
April, 2007 - March, 2011: Supervising Director The Research Center for Radiation Emergency Medicine, National Institute of Radiological Sciences, Chiba, Japan
March, 2011 - Executive Director, National Institute of Radiological Sciences, Chiba, Japan

MEMBERSHIP

Japanese Cancer Association
Japan Hematological Society
Japan Radiation Research Society
American Society of Hematology
American Association for Cancer Research
Board Member of International Association of Radiopathology

PRIZE AND AWARD

April, 1975-March, 1981: Yamagata University, School of Medicine (Yamagata, Japan Awarded the degree of MD April, 1985-March, 1989: Awarded the Degree of Ph D from Graduate School of Medicine, Jichi Medical School (Tochigi, Japan)

MAJOR PROFESSIONAL QUALIFICATIONS

November, 2010 Japan Medical Association Certified Occupational Medicine Physician

PUBLICATIONS in ENGLISH

  1. Akashi M , Kumagaya K, Kondo H, Hirose Y. Concerns of Disaster Medical Assistance Team (DMAT) members about troubles at the nuclear power plant: experience from the Niigata Chuetsu-Oki earthquake, 16 July 2007, in Japan. Health Phys. 98(6):804-809, 2010

  2. Park KD, Jang M, Akashi M . Training programs for radio-nuclear emergency response in the Asian region. Health Phys. 98(6):889-893, 2010

  3. Nakayama F, Hagiwara A, Umeda S, Asada M, Goto M, Oki J, Suzuki M, Imamura T, Akashi M . POST TREATMENT WITH AN FGF CHIMERIC GROWTH FACTOR ENHANCES EPITHELIAL CELL PROLIFERATION TO IMPROVE RECOVERY FROM RADIATION-INDUCED INTESTINAL DAMAGE, International Journal of Radiation Oncology Biology Physics. 78(3), 860-867, 2010

  4. Ishihara H, Tanaka I, Yakumaru H, Chikamori H, Ishihara F, Tanaka M, Ishiwata A, Kurematsu A, Sato A, Ueda J, Akashi M. Circadian Transitions in Radiation Dose-Dependent Augmentation of mRNA Levels for DNA Damage-induced Genes Elicited by Accurate real-time RT-PCR Quantification., Journal of Radiation Research. 51(3), 265-275, 2010

  5. Yamamoto T, Sakaguchi N, Hachiya M, Nakayama F, Yamakawa M, Akashi M . Role of catalase in monocytic differentiation of U937 cells by TPA: hydrogen peroxide as a second messenger. Leukemia. 23(4), 761-769, 2009 (accepted in 14 October 2008)

  6. Tamura T, Cui X, Sakaguchi N, Akashi M . Ginsenoside Rd prevents and rescues rat intestinal epithelial cells from irradiation-induced apoptosis. Food Chem Toxicol. 46(9):3080-3089, 2008

  7. Nakayama F, Muller K, Hagiwara A, Ridi R, Akashi M, Meineke V. Involvement of Intracellular Expression of FGF12 in Radiation-Induced Apoptosis in Mast Cells. J Radiat Res.49(5):491-501, 2008

  8. Motomura K, Hagiwara A, Komi-Kuramochi A, Hanyu Y, Honda E, Suzuki M, Kimura M, Oki J, Asada M, Sakaguchi N, Nakayama F, Akashi M, Imamura T. An FGF1:FGF2 chimeric growth factor exhibits universal FGF receptor specificity, enhanced stability and augmented activity useful for epithelial proliferation and radioprotection. Biochim Biophys Acta. General Subjects. 1780(12): 1432-1440, 2008

    1. Nakayama F, Hagiwara A,Yamamoto T, Akashi M . Hydrogen peroxide as a

    2. potential mediator of the transcriptional regulation of heparan sulphate biosynthesis in keratinocytes. Cell Mol Biol Lett. 13(3):475-492, 2008
  9. Hasegawa S, Koshikawa M, Takahashi I, Hachiya M, Furukawa T, Akashi M, Yoshida S, Saga T. Alterations in manganese, copper, and zinc contents, and intracellular status of the metal-containing superoxide dismutase in human mesothelioma cells. J Trace Elem Med Biol. 22(3):248-255, 2008

  10. Cui X, Kobayashi Y, Akashi M , Okayasu R. Metabolism and the paradoxical effects of arsenic: carcinogenesis and anticancer. Curr Med Chem. 15(22):2293-2304, 2008

  11. Igaki H, Nakagawa K, Uozaki H, Akahane M, Hosoi Y, Fukuyama M, Miyagawa K, Akashi M , Ohtomo K, Maeawa K. Pathological Changes in the Gastrointestinal Tract of a Heavily Radiation-expo at the Tokai-mura Criticality Accident. J Radiat Res. 49(1):55-62, 2007

  12. Kurihara O, Yamada Y, Akashi M, Momose T. REIDAC-A Software Package for Restrospective Dose Assessment in Internal Contamination with Radionuclides. J. Nucl. Sci. Techol. 44(10):1337-1346, 2007

  13. Yamada Y, Fukutsu K, Kurihara O, Akashi M . Influences of Biometrical Parameters on Aerosol Deposition in the ICRP 66 Human Respiratory Tract Model : Japanese and Caucasians. エアロゾル研究 . 22(3):236-243, 2007

  14. Suzuki T, Matsumoto M, Kim E, Yajima, K, Akashi M , Fujimoto, K. Dose Estimation of a Soft X-ray Exposure Incident. Health Physics. Operational Radiation Safety. 91(2) suppl 1:S35-S38, 2006

  15. Takai D, Sang-Hee Park, Takada Y, Akashi M . UV-irradiation induces oxidative damage to mitochondrial DNA primarily through hydrogen peroxide:analysis of 8-oxodGuo by HPLC. Free Radical Research. 40(11) :1138-1148, 2006

  16. Haratake M, Yasumoto K, Ono M, Akashi M , Nakayama M. Synthesis of hydrophilic macroporous chelating polymers and their versatility in the preconcentration of metals in seaweter samples. Analytica Chimica Acta. 561: 183-190, 2005

  17. Iyoda T, Nagata K, Akashi M , Kobayashi Y. Neutrophils accelerate Macrophage-Mediated Digestion of Apoptotic Cells In Vivo as Well as In Vitro. Journal of Immunology. 175(6) :3475-3483, 2005

    1. Ishihara H, Tanaka I, Ishihara F, Suzuki K, Yoshino C, Cheeramakara C, Wan H, Akashi M . Transient reporter RNA assay: quantification of reporter gene mRNA during immediate early response in mammalian cells based on real-time reverse

    2. transcription polymerase chain reaction. Analytical Biochemistry. 341(2) : 369-371, 2005
  18. Kawamura S, Takai D, Watanabe K, Hayashi J, Hayakawa K, Akashi M . Role of Mitochondrial DNA in Cells Exposed to Irradation: Generation of Reactive Oxygen Species (ROS) is Required for G2 Checkpoint upon Irradiation. Journal of Health Science. 51(3): 385-393, 2005

    1. Hachiya M and Akashi M . Catalase Regulates Cell Growth in HL60 Human Promyelocytic Cells:Evidence for Growth Regulation by H 2 O 2 . Radiation Research.

    2. 163: 271-282, 2005
  19. Muramatsu Y, Yoshida S, Ban-nai T, Akashi M . Determination of radionuclides in human and environmental samples from the criticality accident in Tokai-mura, Japan. Journal of Radioanalytical and Nuclear Chemistry. 262(1):129-134, 2004

  20. Suzuki G, Shimada Y, Hayashi T, Akashi M , Hirama T, Kusunoki Y. An Association between Oxidative Stress and Radiation-Induced Lymphomagenesis. Radiation Research. 161: 642-647, 2004

  21. Kondo H, Park S.H., Watanabe K, Yamamoto Y, Akashi M . Polyphenol (-)-epigallocatechin gallate inhibits apoptosis induced by irradiation in human HaCaT keratinocytes. Biochem Biophys Res Commun. 315: 59-64, 2004

  22. Hachiya M, Takada M, Sekikawa K, Akashi M . Endogenous Production of TNFα is a potent trigger of NFκB activation by Irradiation in Human Monocytic Cells THP-1. Cytokine. 25(4): 147-154, 2004

  23. Tanosaki S, Ikezoe T, Heaney A, Said JW, Dan K, Akashi M . Koeffler HP. Effect of ligands of nuclear hormone receptors on sodium/iodide symporter expression and activity in breast cancer cells. Breast Cancer Res Tr. 79(3):335-45, 2003

  24. Miyamoto K, Takeda H, Nishimura Y, Yukawa M, Watanabe Y, Ishigure N, Kouno F, Kuroda N, Akashi M . Validation and Verification of the ICRP Biokinetic Model of 32P:The Criticality Accident in Tokai-mura, Japan. Radiat Prot Dosim. 105: 199-208, 2003

    1. Hirama T, Tanosaki S, Kandatsu S, Kuroiwa N, Kamada T, Tsuji H, Yamada S, Katoh H, Yamamoto N, Tsujii H, Suzuki G, Akashi M . Initial medical Management of patients severely irradiated in the Tokaimura criticality accident. Br. J. Radiol.

    2. 76: 246-253, 2003
    1. Takada Y, Hachiya M, Park SH, Osawa Y, Ozawa T, Akashi M . Role of reactive oxygen species in cells overexpressing manganese superoxide dismutase:

    2. Mechanism for induction of radioresistance. Mol Cancer Res.1: 137-146, 2002
    1. Park SH, Lee YS, Osawa Y, Hachiya M, Akashi M . Hsp25 Regulates the Expression of p21(WAF1/Cip1/Sdi1) through Multiple Mechanisms. J. Biochem

    2. 131: 869-875, 2002
  25. Miyamoto K, Watanabe Y, Yukawa M, Takeda H, Nishimura Y, Ishigure N,Hirama T, Akashi M . Reconstruction of Two Victims Posturing Based on the Induced Radioactivities in Their Bones in the Criticality Accident in Tokai-Mura, Japan. Health Phys 83: 19-25, 2002

  26. Anzai N, Lee Y, Youn B, Fukuda S, Kim Y, Mantel C, Akashi M , Broxmeyer H.E. c-kit associated with the transmembrane 4 superfamily proteins constitutes a functionally distinct subunit in human hematopoietic progenitors. Blood 99: 4413-4421, 2002

  27. Takeda H, Miyamoto K, Yukawa M, Nisimura Y, Watanabe Y, Kim HS, Fuma S, Kuroda N, Kouno F, Joshima H, Hirama T, Akashi M . Bioassay for neutron-dose estimation of three patients in the JCO criticality accident in Tokai-mura by measuring beta-ray emitters. J Radiat Res Sep;42 Suppl:S 129-135, 2001

  28. Muramatu Y, Noda Y, Yonehara H, Ishigure N, Yoshida S, Yukawa M, Tagami K, Ban-Nai T, Uchida S, Hirama T, Akashi M, Nakamura Y. Determination of radionuclides produced by neutron in heavily exposed workers of the JCO criticality accident in Tokai-mura for estimation an individual’s neutron fluence. J Radiat Res Sep;42 Suppl: S 117-128, 2001

  29. Akashi M , Hirama T, Tanosaki S, Kuroiwa N, Nakagawa K, Tuji H, Kato H, Yamada S, Kamata T, Kinugasa T, Ariga H, Maekawa K, Suzuki G,Tujii H. Initial symptoms of acute radiation syndrome in the JCO criticality accident in Tokai-mura. J Radiat Res Sep;42 Suppl:S 157-166, 2001

  30. Nakagawa K, Kozuka T, Akahane M, Suzuki G, Akashi M, Hosoi Y, Ohtomo K. Radiological findings of accidental radiation injury of the fingers: a case report. Health Phys 80: 67-70, 2001

  31. Kubota T, Hirama T, Verbeek W, Kawano S, Chin D.Y, Chumako A, Taguchi H, Koeffler H.P. DNase I hypersensitivity analysis of the human CCAAT enhancer binding protein e (C/EBPe) gene. Leukemia Research 25: 981-995, 2001

  32. Kobayashi Y, Takada Y, Hachiya M, Ando K, Nakajima N, Akashi M . TNFα induces p21 WAF1 but not Bax in colon cancer cells WiDr with mutated p53: important role of protein stabilization. Cytokine 12: 1745-1754, 2000

  33. Osawa Y, Hachiya M, Araki S, Kusama T, Matsushima K, Aoki Y, Akashi M . IL-1 Induces Expression of p21 WAF1 Independently of p53 in High-Passage Human Embryonic Fibroblasts WI38 1 . J Biochem 127: 883-893, 2000

  34. Hachiya M, Osawa Y, Akashi M . Role of TNF in regulation of myeloperoxidase expression in irradiated HL60 promyelocytic cells. Biochim Biophys Acta 1495: 237-249, 2000

  35. Takada Y, Hachiya M, Osawa Y, Hasegawa Y, Hasegawa Y, Ando K, Kobayashi Y, Akashi M . 12-O-tetradecanoylphorbol-13-acetate-induced Apoptosis Is Mediated by Tumor Necrosis Factorα in Human Monocytic U937 Cells. J Biol Chem 274: 28286-28292, 1999

  36. Tanosaki S, Minamihisamatsu M, Ishihara T, Hachiya M, Kumatori T, Akashi M . Chromosome Aberrations in Bone Marrow Cells from Japanese Patients with Thorotrastosis. Radiat Res 152: 128-132, 1999

  37. Akashi M , Oasawa Y, Hachiya M, Koeffler HP. p21 WAF1 expression by an activator of protein kinase C is regulated mainly at the post-transcriptional level in cells lacking p53 : important role of RNA stabilization. J Biol Chem 337: 607-616, 1999

  38. Nose M, Uzawa A, Nomura M, Ikarashi Y, Nakata Y, Akashi M , Suzuki G.. Control of endotoxin shock by the dried preparation of low virulent streptococcus pyogenes OK-432. Cell. Immunol 188: 97-104, 1998

    1. Imamura M, Murata T, Akagi K, Tanaka Y, Imamura M, Inoue K, Mizuma N, Kobayashi Y, Watanabe H, Hachiya M, Akashi M , Furusawa Y, Yamanaka H, Takahash S, Nakano T, Nagaoka S, Ohishi T, Obiya Y, Harada K. Relationship between LET and RBE values for Escherichia coli determined using carbon ion beams from the TIARA cyclotron and HIMAC synchrotron. J Gen Appl Microbiol

    2. 43: 175-177, 1998
  39. Hachiya M, Shimizu S, Osawa Y, Akashi M . Endogenous production of TNF is required for MnSOD exoression by irradiation in the human monocytic cells THP-1. Biochem J 328: 615-623, 1997

    1. Nomura M, Nakata Y, Inoue T, Uzawa A, Itamura S, Nerome K, Akashi M , Suzuki

    2. G. In vivo induction of cytotoxic T lymphocytes specific foe a single epitope introduced into an unrelated molecule. J Immunol Methods 193: 41-49, 1996
    1. Akashi M , Takagi S, Hachiya M. Anticancer agent OK432 induces manganese superoxide dismutase in human granulocytes: possible mechanisms. Int J Cancer

    2. 68: 384-390, 1996
  40. Shiohara M, Akashi M , Gombart AF, Yang R, Koeffler HP. Tumor necrosis factor a: Posttranscriptional stabilization of WAF1 mRNA in p53-deficient human leukemic cells. J Cell Physiol 166: 568-576, 1996

  41. Nakata Y, Matsuda K, Uzawa A, Nomura M, Akashi M , Suzuki G. Administration of Recombinant human IL-1 by Staphylococcus enterotxin B prevents toleranceinduction in vivo. J Immunol 155: 4231-4235, 1995

  42. Osawa Y, Hachiya M, Koefflelr HP, Suzuki G, Akashi M . IL-1 induces expression of WAF1 mRNA in human fibroblasts: mechanisms of accumulation. Biochem Biophys Res Commun 216: 429-437, 1995

  43. Akashi M , Hachiya M, Oasawa Y, Spirin K, Suzuki G, Koeffler HP. Irradiation induces WAF1 expression through p53-independent pathway in KG-1 cell. J Biol Chem 270: 19181-19187, 1995

  44. Akashi M , Hachiya M, Paquette R, Osawa Y, Shimizu S, Suzuki G. Irradiation increases MnSOD mRNA levels in human fibroblasts: possible mechanisms for its accumulation. J Biol Chem 270: 15864-15869, 1995

  45. Hachiya M, H.P. Koeffler, Suzuki G, Akashi M . Tumor necrosis factor and interleukin-1 synergize with irradiation in expression of GM-CSF gene in human fibroblasts. Leukemia 9: 1276-1281, 1995

  46. Suzuki G, Nomura M, Uzawa A, Akashi M , Nakata Y. Impaired CD28-mediated co-stimulation in anergic T cells. Int Immunol 7: 37-43, 1994

  47. Akashi M , Shaw G, Hachiya M, Suzuki G, Koeffler HP. Number and location of AUUUA motifs important for regulation of transiently expressed RNAs. Blood 83: 3182-3187, 1994

  48. Hachiya M, Chumakov A, Miller C, Akashi M , Koeffler HP. Mutant p53 proteins behave in a dominant, negative fashion in vivo. Anticancer Res 14: 1853-1860, 1994

  49. Hachiya M, Suzuki G, H.P. Koeffler, Akashi M . Irradiation increases expression of GM-CSF in human fibroblasts by transcriptional and posttranscriptional regulation. Exp Cell Res 214: 343-350, 1994

  50. Nose M., Aoki Y, Kawase Y, Suzuki G, Akashi M, Akanuma A. In vitro effects of OK-432 on irradiated mouse bone marrow cells. Int J Rad Oncol Biol Phys 29: 631-634, 1994

  51. Hayashi O, Akashi M , Fujime M, Hanazawa K, Kitagawa R. Detection of Interleukin-1 activity in human bladder cancer cell lines. J Urol 151: 750-753, 1994

  52. Uzawa A, Suzuki G, Akashi M , Ohyama H, Akanuma A. Radiosensitivity of CD45 RO+ memory and CD45RO- naive T cells in culture. Radiat Res 137: 25-33, 1994

  53. Kawase Y, Akashi M , Ohtsu H, Aoki Y, Akanuma A, Suzuki G.. Effect of recombinant granulocyte colony-stimulating factor on induction of myeloid leukemias by X-irradiation. Blood 82: 2163-2168, 1993

  54. Akashi M , Hachiya M, Koeffler HP, Suzuki G. Irradiation increases levels of GM-CSF through RNA stabilization which requires an AU-rich region in cancer cells. Biochem Biophys Res Commun 189: 986-993, 1992

  55. Akashi M , Shaw G, Saito M, Koeffler HP. Role of AUUU-sequences in stabilization of GM-CSF RNA in stimulated cell. Blood 78:2005-2012,1991

  56. J-Y Zhou, A Norman, Akashi M, D-L Chen MR, Uskokovic J M, Aurrecoechea WG., Dauben WH, Okamura HP Koeffler. Development of a novel vitamin D3 compound with potent ability to induce HL-60 cell differentiation without modulating calcium metabolism. Blood 78: 75-82, 1991

  57. Miyagi T, Akashi M , Yamato K, Miyoshi I, Koeffler HP. D-factor: Modulation of expression in Fibroblasts. Leukemia Res 15: 441-451, 1991

  58. Akashi M , Loussararian A, Adelman DC, Saito M, Koeffler HP. A role of lymphotoxin in expression of interleukin-6 in human fibroblasts. J Clin Invest 85: 121-129, 1990

  59. Akashi M , Koeffler HP. Control of hematopoietic growth factors. Prog Clin Biol Res. 352: 257-267, 1990

  60. Akashi M , Saito M, Koeffler HP. Lymphotoxin: stimulation and regulation of colony stimulating factors in fibroblasts. Blood 74; 2383-2390, 1989

  61. Akashi M , Sakamoto S, Ohta M, Kitagawa S, Yoshida M, Saito M, Takaku F, Miura Y. Treatment of multiple myeloma with carboquone-prednisolone. Eur J Hematol 42: 265-269, 1989

  62. Akashi M , Takaku F, Nojiri H, Nagai Y, Miura Y, Saito M. Neutral and sialosyl glycosphingolipid composition and metabolism of human T-lymphocytic cell line MOLT-3 cells: distinctive changes as markers specific for their differentiation. Blood 72: 469-479, 1988

  63. Komatsu N, Yoshida M, Eguchi M, Akashi M , Sasaki R, Sakamoto S, Miura M. Simultaneous expression of lymphoid and myeloid phenotypes in acute leukemia arising from myelodysplastic syndrome. Amer J Hematol 28: 103-106, 1988

  64. Akashi M , Nojiri H, Saito M. Involvement of gangliosides in E-rosette forming

capacity of human leukemia cell line MOLT-3 cells. Glycoconjugates 8: 385-386, 1985

PUBLICATIONS in ENGLISH (Review)

  1. Akashi M , Tamura T, Tominaga T, Abe K, Hachiya M, Nakayama F. Radiation Damage in the Human Body - Acute Radiation Syndrome AND multiple organ failure. Nuclear Engineering and Technology. 6(3) : 231-238, 2006

  2. Akashi M . Role of infection and bleeding in multiple organ involvement and failure. Br J Radiol. Suppl 27 : 69-74, 2005

  3. Hirama T and Akashi M . Multi-organ involvement in the patient who survived the Tokai-mura criticality accident. Br J Radiol. Suppl 27 : 17-20, 2005

  4. Akashi M and Koeffler HP. Li-Fraumeni syndrome and the role of p53 tumor suppressor gene in cancer susceptibility. Clinical Obsterics and Gynecology. Lippiincott-Raven Publishers MD 41, 172-199, 1998

  5. Akashi M and Koeffler HP. Colony stimulating factors: regulation of production. in: Proceedings of Modern Tends in Human Leukemia (1992) Springer-Verlag GmbH & Co. KG Heiderberg pp83-92

  6. Akashi M and Koeffler HP. Colony stimulating factors: regulation of production. in: Proceedings of Modern Tends in Human Leukemia Springer-Verlag GmbH & Co. KG Heiderberg 35:83-92, 1992

  7. Akashi M and Koeffler HP. Regulation of induction of hematopoietic growth factors. in: Hematopoietic Growth Factors in Clinical Applications. Metelsmann R, Hermann F (eds) Marcel Becker and Co., New York, New York. 41-62, 1990.

  8. Akashi M , Yamato K, Aoki Y, Koeffler HP. Colony stimulating factors: regulation of production. in: The proceedings of international symposium on myelodysplastic syndrome and cytokine. ELSVIER, Amsterdam, pp79-90, 1990.

  9. Akashi M , Koeffler HP. Control of hematopoietic growth factors. in: The Biology of Hematopoiesis. Dainiak N, Crokite PE, McCaffrey R, Shadduck RK (eds) Prog Clin Biol Res. 352;257-267,1990.

PROCEEDINGS in ENGLISH

  1. Akashi M . International Cooperation in Radiation Emergency Medical Preparedness : Establishement of a Medical Network in Asia. Radiation Health Risk Sciences : Proceeding of the First International Symposium of the Nagasaki University Global COE Program”Global Strategic Center for Radiation Helath Risk Control”. 254-259, 2008

  2. Mori T, Machinami R, Hatakeyama S, Fukutomi K, Kato Y, Akashi M , Fukumoto M, Aoki I. The 2002 Results of the First Series of Follow-up Studies on Japanese Thorotrast Patients and their Relationships to Autopsy Series. Proceedings of the 9 th International Conference on Health Effects of Incorporated Radionuclides Emphasis on Radium, Thorium, Uranium and their Daughter Products. pp31-46, 2005

  3. Kimura S, Akashi M , Kumar SS, Shiraishi K, Fujimoto K. Thorium Determination in Thorotrast Patient Organs Using Inductively Coupled Plasma Mass Spectrometry and Imaging Plate Autoradiography. ISMAS Silver Jubilee Symposium on Mass Spectrometry 1.2. pp561-564, 2003

  4. Muramatsu Y, Ishigure N, Noda Y, Yonehara H, Yoshida S, Yukawa M, Akashi M . Estimation of radiation doses by determining radionuclides produced in heavily exposed patients of the Tokai-mura critically accident. Proc. of the Fourth Japan-France Workshop on Radiobiology and Isotopic Imaging. pp15-19, 2002

  5. Watanabe Y, Yukawa M, Miyamoto K, Takada H, Nishimura Y, Akashi M , Fujimoto K, Fuma S, Hirama T, Ishigure N, Joshima H, Kouno F. Neutron fluence distribution by bone and hair. Proceedings of International Symposium on the Criticality Accident in Tokaimura. Medical Aspects of Radiation Emergency.( NIRS-M-146) pp102-108, 2001

  6. Akashi M . Dose estimation of victims severely exposed based on initial symptoms in the criticality accident in Tokaimura. Proceedings of International Symposium on the Criticality Accident in Tokaimura. Medical Aspects of Radiation Emergency. (NIRS-M-146) pp72-80, 2001

  7. Akashi M . Initial symptoms of Victims in the Tokaimura Criticality Accident. The Medical Basis for Radiation-Accident Preparedness : Proceeding of the Fourth International REAC/TS Conference on the Medical Basis for Radiation-Accident Preparedness March 2001 Orlando, Florida. pp 303-312

    1. Muramatsu Y, Ishigute N, Noda Y, Yonehara H, Yoshida S, Yukawa M, Tagami K, Bannai T, Uchida S, Akashi M , Hirama T, Nakamura Y. Estimation of radiation

    2. doses for three exposed patients in the Tokai-mura accident based on 24Na in their biological materials. Proceedings of International Symposium on the Criticality Accident in Tokaimura. Medical Aspects of Radiation Emergency. (NIRS-M-146) pp90-100, 2001
  8. Akashi M . The Second Japan -France Workshop on Radiobiology and Isotopic Imaging. Late effect angiophathy after the accident of exposure to an 192iridium source in Chiba. Fontenay aux Roses, France. February, 1998

  9. Akashi M. The seventh coordination meeting of WHO collaborating centers in REMPAN. Radiation emergency medical preparedness in Japan. WHO, Geneva pp150-155, 1997

  10. Akashi M . Leukemia in Hiroshima and Nagasaki and Experimental Leukemogenesis by Irradiation. Sixth Symposium on Chernobyl-related Hearth Effects (Tokyo, 10-11 December 1997, by Radiation Effects Association) pp163-164, 1997

  11. Akashi M . Report of the sixth coordination meeting of WHO collaborating centers in REMPAN. WHO, Geneva. An accident of exposure to an 192-iridium source in Chiba, Japan: Angiopathy 22 years after exoposure. pp64-72, 1996

  12. Akashi M . Administration of stable Iodine for exposure to radioactive Iodide. Forth Symposium on Chernobyl-related Health Effects (Tokyo, 12-13 December 1995, by Radiation Effects Association) pp114-115, 1996

  13. Akashi M , Hachiya M, Shimizu S, Osawa Y and Suzuki G. Irradiation increases MnSOD gene in human fibroblasts: possible mechanism for its accumulation. Proceedings of the Second Workshop on Physical and Biologiccal Research with Heavy Ions. NIRS-M99:84-90, 1993 Chiba

  14. Akashi M , Mizoe J, Hachiya M, Takagi S, and Akanuma A. Effect of Different Qualities of Irradiation on Expression of Granulocyte/Macrophage Stimulating Factor mRNA in Human Cells. Proceedings of the Second Workshop on Physical and Biological Research with Heavy Ions. August 31, 1992 Chiba. pp27-30.