Name: Kazuo Neriishi
Dr. Neriishi was graduated with his MD from Nagasaki University School of Medicine where he also did his residency in Internal Medicine. He later earned PhD from Hiroshima University School of Medicine. He is board-certified in Internal Medicine as well as Occupational Medicine and currently is Consultant, Department of Clinical Studies, Radiation Effects Research Foundation (RERF) in Hiroshima. His research interests are radiation epidemiology, oxidative stress and radiosensitivity.
Birth Date: August 1, 1950
Birth Place: Tokyo, Japan
Marital Status: Married, one son
Residence Address: 3-29-17-801 Nakasuji,
Asaminami-ku, Hiroshima, Japan 731-0122,
Occupation: Medical Doctor (Internist)
Present Status: Consultant, Department of Clinical Studies, Radiation Effects Research Foundation
Office Address: 5-2 Hijiyama Park, Minami-Ku, Hiroshima, Japan, 732-0815,
(Present address: Yachiyo Hospital, 448 Katsuta Yachiyo, Akitakata, Japan)
Education: Graduated from Nagasaki University School of Medicine in 1976.
Received Ph.D. from Hiroshima University School of Medicine in 1986
Professional Training: Medical Resident at Nagasaki University School of Medicine in 1976-78
Research Fellow at Miami University School of Medicine in 1981-84
License: Japanese National License of Medicine
Diploma, Japanese Board of Internal Medicine
Diploma, Japanese Board of Occupational Medicine
MEST No. 50359452(registry No.0004)
Membership: Japan Society of Internal Medicine
Japan Society of Public Health
Japan Society of Radiation Research
Society of Radiation Research (USA)
International Society for Free Radical Research
Major Research Interest: Radiation Epidemiology, Oxidative Stress and Radiosensitivity
2005 WHO Chernobyl Forum expert, Geneva
2003 IAEA professional expert, Malaysia seminar
2001-2008 Deputy, Committee of Medical Management for the Exposed, Atomic Energy Safety Commission, Cabinet Office of Japanese Government
1999-present Member, Committee of Health Care for JCO Criticality Accident in Tokaimura, Ibaragi Prefecture
1997-2003 Secretariat, NIS Researcher Exchange program for Chernobyl Nuclear Accident, Ministry of Foreign Affairs of Japan
1. K. Neriishi, Mori M, Takamori M. A case of chorea complicating polycythemia vera. Rinsho Shinkeigaku 1980 Apr;20(4):221-4 (Japanese)
2. K. Neriishi, A case of thyroid cancer after radiotherapy for tongue cancer. J Hiroshima Med Ass. 33:59-62, 1980. (Japanese)
3. L. Frank, K. Neriishi. Endotoxin treatment protects vitamin E-deficient rats from pulmonary O2 toxicity. Am J Physiol 1984 Sep;247(3 Pt 2):R520-6.
4. K. Neriishi, L. Frank, Castration prolongs tolerance of young male rats to pulmonary O2 toxicity, Am. J. Physiol. 247, R475-R481, (1984).
5. K. Neriishi, L. Frank. Effects of sex hormone in oxygen toxicity. Igaku no Ayumi . 132:141-143, 1985.
6. Y. Hosoda, K. Neriishi, Angiotensin converting enzyme. J. Jpn Med. Ass. 96:1871-73, 1986.
7. K. Neriishi, S. Akiba, Ecogenetics in atomic bomb survivors. Peroxide Research 10:124-126, 1986 (Japanese).
8. K. Neriishi, L. Frank. Effects of sex hormone in paraquat intoxication. J. Hiroshima Med. Ass. 40:61-63, 1987.
9. Akiba S, Neriishi K, Blot WJ, Kabuto M, Stevens RG, Kato H, Land CE. Serum ferritin and stomach cancer risk among a Japanese population. Cancer. 1991 67(6):1707-12.
10. K. Neriishi, D. O. Stram, M. Vaeth, S. Mizuno and S. Akiba, The observed relationship between the occurrence of acute radiation effects and leukemia mortality among A-bomb survivors. Radiat. Res. 125, 206-13 (1991).
11. K.Neriishi, Possible involvement of a free-radical mechanism in the late effects of A-bomb radiation. pp 365-368, In Oxygen Radicals. Ed by K. Yagi, M. Kondo, E. Niki, T. Yoshikawa, 1992.
12. RG Stevens and K.Neriishi, Iron and oxidative damage in human cancer. In Biological Consequences of Oxidative Stress. Ed by L. Spatz and A. D. Bloom. Oxford University Press 1992.
13. K. Neriishi, Y. Yoshimoto, R. L. Carter, T. Matsuo, M. Ichimaru, M. Mikami, T. Abe, K. Fujimura and A. Kuramoto. Monoclonal gammopathy in atomic bomb survivors. Radiat. Res. 133, 351-9 (1993).
14. K. Neriishi, Vitamin E and radiation injury: A possible protective role for antioxidants in individual differences in atomic bomb radiation injury. In Vitamin E - Its usefulness and health and in curing diseases M. Mino, Ed. pp. 187-94 Japan Sci. Soc. Press, Tokyo/S. Karger, Basel, 1993.
15. Kabuto M, Imai H, Yonezawa C, Neriishi K, Akiba S, Kato H, Suzuki T, Land CE, Blot WJ. Prediagnostic serum selenium and zinc levels and subsequent risk of lung and stomach cancer in Japan. Cancer Epidemiol Biomarkers Prev 1994 Sep;3(6):465-9.
16. R. G. Stevens, B. I. Graubard, R.S. Micozzi, K. Neriishi, B. S. Blumberg, Moderate elevation of body iron level and increased risk of cancer occurrence and death. Int. J. cancer 56:364-369, 1994.
17. T. Matsuo, E. Nakashima, R.L. Carter, K. Neriishi, K. Mabuchi, M. Akiyama, K. Shimaoka, K. Kinoshita, M. Tomonaga, M. Ichimaru, Anti-Human T-lymphotrophic virus type antibodies in atomic bomb survivors. J. Radiat. Res. 36:8-16, 1995.
18. K. Neriishi, F. L. Wong, E. Nakashima, M. Otake, K. Kodama and K. Choshi, Relationship between cataract and epilation in atomic bomb survivors. Radiat. Res. 144, 107-13 (1995).
19. K. Neriishi, S. Akiba, T. Amano, T. Ogino, K. Kodama, Prevalence of hepatitis surface antigen, hepatitis B e antigen and antibody, and antigen subtypes in atomic bomb survivors. Radiat. Res. 144, 215-21 (1995).
20. S. Ban, J.B. Cologne, K. Neriishi, Effect of radiation and cigarette smoking on expression of FUdR-induced common fragile sites in human peripheral lymphocytes. Mut. Res. 334:197-203, 1995.
21. E. Nakashima, R.L. Carter, K. Neriishi, S. Tanaka, S. Funamoto, Height reduction among prenatally exposed atomic-bomb survivors: a longitudinal study of growth. Health Phys. 68:766-772, 1995.
22. Y. Hosoda, S. Sasagawa, K. Neriishi, Epidemiology of radiation workers. Sangyo Eisei 38:107-118, 1996 (Japanese).
23. K. Neriishi, Epilation and late effects of radiation. Environment and Health 1996:9(2): 49-67 (Japanese)
24. K. Neriishi E. Nakashima, Persistent inflammation in survivors. RERF Update 10:10-11, 1999.
25. M. Kabuto, S. Akiba, RG. Stevens, K.Neriishi, CE. Land, A prospective study of estradiol and breast cancer in Japanese women. Cancer Epidemiology Biomarkers Prevention 9:575-579, 2000.
26. K.Neriishi, E. Nakashima, Relationship between radiation dose and smoking in inflammation makers in A-bomb survivors. Nagasaki Medical Journal 75:51-54, 2000 (Japanese).
27. E. Nakashima, K. Neriishi, Analysis of inflammatory test measurement in Atomic Bomb survivors with principal component analysis. J. Hiroshima Med Ass 53:267-269, 2000 (Japanese).
28. K. Neriishi, Ezaki H, Arihiro K, Okamoto H, Thyroid lymphoma of mucosa-associated lymphoid tissue with monoclonal gammopathy occurring in an atomic bomb survivor: report of a case. Surg Today 2000; 30(2):202-6
29. K. Neriishi, Activity of medical team of Ministry of Health and Welfare at the Tokaimura Criticality Accident. Innervision 2000:15(2): 16-17. (Japanese)
30. S. Nagataki, K. Neriishi, Issues involved in long-term follow-up of persons after radiation exposure. In Medical Management of Radiation Accidents, 2nd edition, 2001. Ed by Gusev IA, Guskova AK, Mettler FA Jr. CRC press.
31. K. Neriishi, E. Nakashima, RR. Delongchamp, Persistent subclinical inflammation among atomic-bomb survivors. Int. J. Radiat. Biol. 2001:77(4): 475-82
32. K. Neriishi, Risk study on radiation. Proceedings of the Society for Risk Analysis, Japan Section 14: 17-20, 2001 (Japanese).
33. K. Neriishi, E. Nakashima, Persistent inflammation in A-bomb survivors. Progress of Vitamin E research. 11:148-152, 2001 (Japanese).
34. K. Neriishi and E Nakashima, An analysis of persistent inflammation among atomic bomb survivors with respect to sex and age at the time of bombings. In Radiation and Homeostasis. Ed by T. Sugihara, O. Nikaido, O. Niwa, pp 71-74, 2002. (International Congress Series (2002) 1236:71-74)
35. The Endogenous Hormones and Breast Cancer Collaborative Group. Endogenous Sex Hormones and Breast Cancer in Postmenopausal Women: Reanalysis of Nine Prospective Studies (K. Neriishi, et al.,). J Natl Cancer Inst 2002; 94: 606-616.
36. K. Neriishi, E. Nakashima, Gen Suzuki. Relationship between growth retardation and inflammation among A-bomb survivors. Nagasaki Medical Journal 77:227-30, 2002 (Japanese).
37. K. Neriishi, E. Nakashima, G. Suzuki, Monoclonal gammopathy of undetermined significance in atomic bomb survivors: Incidence and transformation to multiple myeloma. Br. J. Hematol. 2003 May;121(3):405-10.
38. Key TJ, Appleby PN, Reeves GK, Roddam A, Dorgan JF, Longcope C, Stanczyk FZ, Stephenson HE Jr, Falk RT, Miller R, Schatzkin A, Allen DS, Fentiman IS, Wang DY, Dowsett M, Thomas HV, Hankinson SE, Toniolo P, Akhmedkhanov A, Koenig K, Shore RE, Zeleniuch-Jacquotte A, Berrino F, Micheli A, Krogh V, Sieri S, Pala V, Venturelli E, Secreto G, Barrett-Connor E, Laughlin GA, Kabuto M, Akiba S, Stevens RG, Neriishi K, Land CE, Cauley JA, Kuller LH, Cummings SR, Helzlsouer KJ, Alberg AJ, Bush TL, Comstock GW, Gordon GB, Miller SR; Endogenous Hormones Breast Cancer Collaborative Group. Body mass index, serum sex hormones, and breast cancer risk in postmenopausal women. J Natl Cancer Inst. 2003 Aug 20;95(16):1218-26.
39. A. Minamoto, H. Taniguchi, N. Yoshitani, S. Mukai, T.Yokoyama, T. Kumagami, Y. Tsuda, H. K. Mishima, T. Amemiya, E. Nakashima, K. Neriishi, A. Hida, S. Fujiwara, G. Suzuki, M. Akahoshi. Cataract in Atomic Bomb Survivors. Int. J. Radiat. Biol. 2004 May 80: 339-345.
40. K.Neriishi, Psychological care activities after Chernobyl Power Plant accident. Kokoro To Shakai (Soul and Society) 2004 115:44-51 (Japanese).
41. Cologne JB, Sharp GB, Neriishi K, Verkasalo PK, Land CE, Nakachi K. Improving the efficiency of nested case-control studies of interaction by selecting controls using counter matching on exposure. Int J Epidemiol. 2004 33:485-92.
42. Y. Tsuda, T. Kumagami, A. Minamoto, H. Taniguchi, N. Yoshitani, S. Mukai, T.Yokoyama, H. K. Mishima, T. Amemiya, E. Nakashima, K. Neriishi, A. Hida, S. Fujiwara, G. Suzuki, M. Akahoshi. Ophthalmic study in Atomic Bomb Survivors. J. Hiroshima Med Ass. 2004 57: 336-8. (Japanese).
43. T. Yokoyama, A. Minamoto, N. Yoshitani, S. Mukai, H. K. Mishima, H. Taniguchi, T. Kumagami, Y. Tsuda, T. Kitaoka, E. Nakashima, K. Neriishi, A. Hida, M. Imaizumi, S. Fujiwara, G. Suzuki, M. Akahoshi, Risk factors of cataract in Atomic Bomb survivors, Nagasaki Medical Journal 79: 237-241, 2004 (Japanese).
44. E. Nakashima, K. Neriishi, A. Minamoto, S. Funamoto, Statistical analysis of cataract prevalence in Atomic Bomb survivors, 2000 – 2002. Nagasaki Medical Journal 79: 234-6, 2004 (Japanese).
45. T. Kondrashova, K. Neriishi, S. Ban, T. Ivanova, L. Krikunova, N. Shentereva, I. Smirnova, I. Zharikova, M. Konova, S. Taira, A. Tsyb, Frequency of hemochromatosis gene (HFE) mutations in Russian healthy women and patients with estrogen-dependent cancers. BBA, Molecular basis of disease, 1762(1):59-65, 2005
46. E. Nakashima, K. Neriishi, A. Minamoto. A Reanalysis of Atomic-bomb Cataract Data, 2000-2002: A Threshold Analysis. Health Physics 90(2): 154-60 2006.
47. M. Imaizumi, T. Usa, T. Tominaga, K. Neriishi, M. Akahoshi, E. Nakashima, K. Ashizawa, A. Hida, M. Soda, S. Fujiwara, M. Yamada, E. Ejima, N. Yokoyama, M. Okubo, K. Sugino, G. Suzuki, R. Maeda, S. Nagataki, K. Eguchi, Radiation dose-response relationships for thyroid nodules and autoimmune thyroid diseases in Hiroshima and Nagasaki atomic bomb survivors 55-58 years after radiation exposure. JAMA. 2006;295:1011-1022.
48. WHO Chernobyl Forum expert group, Non-cancer and non-thyroid health effects (The eye and cataractogenesis). In Health effects of the Chernobyl Accident and special health case programs, 2001. Ed by Bennett B, Repacholi M, Carr Z, WHO, Geneva, 2006.
49. K. Neriishi, E. Nakashima, S. Fujiwara, M. Akahoshi: Postoperative cataract in atomic-bomb survivors; Dose response relationship, indirect effect factors and threshold. Hiroshima Medical Journal 59:330-2, 2006 (Japanese).
50. E. Nakashima, Y. Fujimoto, K. Neriishi, A. Minamoto, Analysis of postoperative cataract prevalence from atomic bomb survivors with decision uncertainty. Nagasaki Medical Journal 81: 229-32, 2006 (Japanese).
51. K. Neriishi, K. Nakachi, G. Sharp, H. Eguchi, E. Grant, J.B. Cologne, C. Land, R. Stevens, S. Izumi, Radiation effects on sex hormones and growth factors in postmenopausal A-bomb survivors: Fundamental analysis in controls of a case control study of breast cancer in atomic bomb survivors. Nagasaki Medical Journal 81: 233-39, 2006 (Japanese).
52. K. Neriishi, Rehabilitation program for residents at radiation contaminated area caused by Chernobyl nuclear plant accident. JAMMRA (Japanese Association for Medical Management of Radiation Accident) 15:15-17, 2007 (Japanese).
53. K. Neriishi, E. Nakashima, A. Minamoto, S. Fujiwara, M. Akahoshi, H.K. Mishima, T. Kitaoka, R. E. Shore, Postoperative cataract cases among atomic bomb survivors: Radiation dose response and threshold. Radiat. Res 168: 404-408, 2007.
54. Nakashima E, Akahoshi M, Neriishi K, Fujiwara S. Systolic blood pressure and systolic hypertension in adolescence of atomic bomb survivors exposed in utero. Radiat Res. 2007 Nov;168(5):593-9.
55. E. Nakashima, K. Neriishi, A. Minamoto, Comparison of methods for ordinal lens opacity data from Atomic-bomb survivors: Univariate worse-eye method and bivariate GEE method using global odds ratio. Ann Instit Statistic Mathem 60: 465-482, 2008.
56. Fujiwara S, Suyama A, Cologne JB, Akahoshi M, Yamada M, Suzuki G, Koyama K, Takahashi N, Kasagi E, Grant EJ, Lagarde E, Hsu WL, Furukawa K, Ohishi W, Tatsukawa Y, Neriishi K, Takahashi I, Ashizawa K, Hida A, Imaizumi M, Nagano J, Cullings HM, Katayama H, Ross NP, Kodama K, Shore RE. Prevalence of adult-onset multifactorial disease among offspring of atomic bomb survivors. Radiat Res. 2008 170(4):451-7.
57. Imaizumi M, Ashizawa K, Neriishi K, Akahoshi M, Nakashima E, Usa T, Tominaga T, Hida A, Sera N, Soda M, Fujiwara S, Yamada M, Maeda R, Nagataki S, Eguchi K. Thyroid diseases in atomic bomb survivors exposed in utero. J Clin Endocrinol Metab. 2008 93(5):1641-8.
58. Blakely EA, Kleiman NJ, Neriishi K, Chodick G, Chylack LT, Cucinotta FA, Minamoto A, Nakashima E, Kumagami T, Kitaoka T, Kanamoto T, Kiuchi Y, Chang P, Fujii N, Shore RE. Radiation cataractogenesis: epidemiology and biology. Radiat Res. 2010 173(5):709-17.
59. Hsu WL, Tatsukawa Y, Neriishi K, Yamada M, Cologne J, Fujiwara S. Longitudinal trends of total white blood cell and differential white blood cell counts of atomic bomb survivors. J Radiat Res (Tokyo). 2010;51(4):431-9.
60. Ashizawa K, Imaizumi M, Usa T, Tominaga T, Sera N, Hida A, Ejima E, Neriishi K, Soda M, Ichimaru S, Nakashima E, Fujiwara S, Maeda R, Nagataki S, Eguchi K, Akahoshi M. Metabolic cardiovascular disease risk factors and their clustering in subclinical hypothyroidism. Clin Endocrinol (Oxf). 2010 72(5):689-95.
61. Shore RE, Neriishi K, Nakashima E. Epidemiological Studies of Cataract Risk at Low to Moderate Radiation Doses: (Not) Seeing is Believing. Radiat Res 2010 174(6):889-94.
62. Neriishi K, A hypothesis: Effects of malnutrition exposure in prenatally or natally exposed A-bomb survivors. J Clin Exp Med 2010 235: 863-6 (Japanese).
63. Miles EF, Tatsukawa Y, Funamoto S, Kamada N, Nakashima E, Kodama Y, Seed T, Kusonoki Y, Nakachi K, Fujiwara S, Akahoshi M, Neriishi K, Biomarkers of radiosensitivity in A-bomb survivors pregnant at the time of bombings in Hiroshima and Nagasaki. ISRN Obstetrics and Gynecology Vol. 2011, Article ID 264978, 11 pages doi:10.5402/2011/264978
64. Nakashima E, Fujii Y, Neriishi K, Minamoto A, Assessment of misclassification in a binary response: Recovering information on clinically significant cataract prevalence from cataract surgery data in atomic-bomb survivors. (In press)
65. Minamoto A, Neriishi K, Nakashima E, UV radiation may explain intercity difference for cataract in A-bomb survivors. J Photochem Photobiol: Biol (accepted)
66. Grant EJ, Neriishi K, Cologne J, Eguchi H, Hayashi T, Geyer S, Izumi S, Nishi N, Land C, Stevens RG, Sharp GB, Nakachi K, Effects of radiation on breast cancer-related serum hormone and growth-factor levels in healthy female A-bomb survivors. (Submitted)