CURRICULUM VITAE

Al WILEY, JR. MD, PhD, FACR

Gordon K. Livingston, Ph. D.

EDUCATION

B.S. (Major: Forestry)
Utah State University
Logan, UT

M.S., (Major: Genetics)
Oregon State University
Corvallis, OR

Ph.D. (Major: Genetics)
University of Washington
Seattle, WA

Post-doctoral Fellowship
(Radiobiology)
University of Nijmegen
Nijmegen, The Netherlands

EMPLOYMENT HISTORY

Technical Director, Cytogenetics Biodosimetry Laboratory, Radiation Emergency Assistance Center/Training Site, Oak Ridge Institute for Science and Education, Oak Ridge, TN 37831 (March 2006 - present). Project: Re-establishment of the Cytogenetic Biodosimetry Laboratory at REAC/TS.

National Research Council! NIOSH Senior Research Associateship Award, (April 1, 2005- February 28, 2006). Project Title: Automated Cytogenetic Analysis of Radiation Workers with Internal Deposits of Plutonium.

Occupational and Environmental Health Consultant, 10563 Swanson Court, Cincinnati, OH 45249-3630 (1999 - 2005). Chromosome testing and consulting related to medical genetics and human risk assessment. Studies involved occupational and environmental exposures to hazardous agents.

Sr. Toxicologist, Health Effects Department, DynCorp of Colorado, Inc., DOE Rocky Flats Environmental Technology Site, Golden, Colorado (1996 - 1999). Served as the Site Coordinator responsible for data collection for the DOE Epidemiology Surveillance Program at the Rocky Flats Environmental Technology Site involving over 3,500 workers. Also conducted cytogenetic evaluations on76 former plutonium workers as part of the Former Radiation Worker Recall Program.

Research Associate Professor, Department of Environmental Health, University of Cincinnati College of Medicine, Cincinnati, Ohio (1986 - 1996). Directed laboratory research devoted to somatic cell genetic toxicology and environmental mutagenesis with emphasis on human population monitoring. Objectives included the development, validation and application of cellular biomarkers of environmental adversity and toxic response. Approaches included mechanisms of cellular genetic toxicity such as chromosomal aberrations, sister-chromatid exchange, aneuploidy and micronuclei based on analysis of lymphocytes and epithelial cells.

Director, Environmental Toxicology, Division of Occupational and Environmental Health, Department of Family and Community Medicine, University of Utah Medical Center, Salt Lake City, Utah (1982 -1986). Directed an environmental toxicology laboratory involving research, development, and application of new methods for monitoring humans with potential exposure to carcinogens and mutagens in the workplace. Investigations involved sampling, processing, and evaluation of cellular specimens directly or following short-term culture for measurement of genotoxic endpoints associated with environmental exposure. Human studies included exposures to asbestos, ethylene oxide, formaldehyde, styrene, pesticides, tobacco, antineoplastic drugs, coke oven emissions as well as ionizing and nonionizing radiation.

Technical Director, Cytogenetics Laboratory, Department of Pediatrics, University of Utah Medical Center, Salt Lake City, Utah (1978 - 1982). Supervised five cytogenetic technicians performing diagnostic chromosome studies on patient specimens, including peripheral blood, bone marrow, amniotic fluid, and skin fibroblasts. This fullservice laboratory operated as part of a state-wide medical genetics program and karyotyped over 600 specimens per year. In addition to directing the clinical cytogenetics program, research involved studies in human genetic toxicology and environmental mutagenesis.

SCHOLASTIC HONORS, SCHOLARSHIPS AND FELLOWSHIPS

2005 Senior Research Associateship, National Research Council/NIOSH
1994 NIOSH Alice Hamilton Science Award for Occupational Safety and Health
NIH National Research Service Award (3 years) University of Utah, Salt Lake City, UT
Faculty Fellowship, University ofNijmegen, The Netherlands
Weyerhaeuser Company Fellowship, University of Washington, Seattle, W A
National Defense Education Act Title N Fellowship, University of Washington, Seattle, WA

PEER REVIEWED PUBLICATIONS

Romm H, Wilkins RC, Coleman CN, Lillis-Hearne PK, Pellmar TC, Livingston GK, Awa AA, Jenkins MS, Yoshida MA, Oestreicher U, Prasanna PGS: Biological dosimetry by the triage dicentric chromosome assay- Potential implications for treatment of acute radiation syndrome in radiological mass casualties. In press: Radiat. Res.

Ainsbury EA, Livingston GK, Abbott MG, Moquet J, Hone P, Jenkins MS, Christensen DM, Lloyd DC and Rothkamm K: Interlaboratory variation in scoring dicentric chromosomes in a case of partial-body x-ray exposure: Implications for biodosimetry networking and cytogenetic 'triage' mode scoring. Radiat. Res. 172:746-752, 2009

Blakely WF, Carr Z, Chu M, Dayal-Drager R, Fujimoto K, Hopmeir M, Kulka U, Lillis-Hearne, P, Livingston GK, Lloyd DC, Maznyk N, Perez MD, Romm H, Takashima Y, Voisin P, Wilkins R, Yoshida M: Meeting Report - WHO 1 st Consultation on the Development of a Global Biodosimetry Laboratories ~etwork for Radiation Emergencies (BioDoseNet). Radiat. Res. 171: 127-139,2009.

Wilkins RC, Romm H, Kao TC, Awa AA, Yoshida MA, Livingston GK, Jenkins MS Oestreicher U, Pellmar TC and Prasanna PGS: Inter-laboratory comparison of the dicentric chromosome assay for radiation biodosimetry in mass casualty events. Radiat. Res. 169: 551-560, 2008.

Sigurdson A.J. et al. (32 co-authors): International study of factors affecting human chromosome translocations. Mutat. Res. 652: 112-121, 2008.

Livingston G.K., Falk R.B., Schmid E.: Effect of occupational radiation exposures on chromosome aberration rates in former plutonium workers. Radiat. Res. 166:89-97,2006.

Peace, B.E., Livingston, G.K., Silberstein, E.B., Loper, lC.: A case of elevated spontaneous micronucleus frequency derived from chromosome 2. Mutation Research 430:109-119, 1999.

Lemasters, G.K., Lockey, lE., Olsen, D.M., Selevan, S.G, Wilson, T.M., Livingston, G.K., New, G.R: Comparison of internal dose measures of solvents in breath, blood and urine and genotoxic changes in aircraft maintenance personnel. Drug and Chemical Toxicology 22(1)181- 200,1999.

Lippoli, C.M., Livingston, G.K., Schumann, B.L., Srivastava, A.K.: Structural and numerical chromosome aberrations in a metabolically competent human lymphoblast cell line (MCL-5). Mutagenesis 13:275-280, 1998.

Livingston, G.K., Jensen, R.H., Hinnefeld, J.D., Pratt, G., Silberstein, E.E., Bigbee, W.L., Langlois, R.G., Grant, S.G., Shukla, R.: Radiobiological evaluation of immigrants from the vicinity ofChernobyl. International Journal of Radiation Biology 72: 703-713, 1997.

Hayes R.B., Klein S., Suruda A., Schulte P., Boeniger M., Stewart P., Livingston G.K., Oesch F.: 0 6 - Alkylguanine DNA alkyltransferase activity in student embalmers. American Journal of Industrial Medicine 31: 361-365, 1997.

Lemasters G.K., Livingston G.K., Lockey J.E., Olsen D.M., Shukla R., New G., Selevan S.G., Yiin J.H.: Genotoxic changes after low level solvent and fuel exposure on aircraft maintenance personnel. Mutagenesis 12:237-243, 1997.

Warshawsky D., Livingston G.K., Fonouni-Fard M., LaDow K.: Induction of micronuclei and sister chromatid exchanges by polycyclic and N-heterocyclic aromatic hydrocarbons in cultured human lymphocytes. Environ. Molec. Mutag. 26:109-118,1995.

Radack, K.L., Pinney, S.M., Livingston, G.K.,: Sources of variability in the human lymphocyte micronucleus assay: A population-based study. Environ. Molec. Mutag. 26:26-36, 1995.

Linz, D.H., Suskind, R.R., Rice, C.H., Shukla, R., Keebler, PJ., Pflaumer, J.E., McKay, R.T., Livingston, G.K., and Lockey, J.E.: Health status of pesticide applicators with attention to the peripheral nervous system. 1. Agromed. 1 :23-42, 1994.

Workman, M.L., and Livingston, G.K.: Testing the sensitivity of a biologic assay for mutagenicity. Nursing Research 42:373-375, 1993.

Suruda, A., Schulte, P., Boeniger, M., Hayes, R.B., Livingston, G.K., Steenland, K., Steart, P., Herrick, R., and Drought, D.: Cytogenetic effects of formaldehyde exposure in students of mortuary science. Cancer Epidem., Biomarkers and Prevention, 2:453-460, 1993.

Livingston, G.K., Foster, A.E., Elson, H.R.: The effect of in vivo exposure to 131Iodine on the frequency and persistence of micronuclei in human lymphocytes. J. Tox. Env. Health 40:373- 381, 1993.

Boucher, R., Livingston, G.K., Que Hee, S.S.: The in-vitro micronucleus bioassay of human peripheral lymphocytes for adriamycin in the presence of cyclophosphamide and urines of patients administered anticancer drugs. Env. Molec. Mutagenesis. 21 :372-382, 1993

Olson, B.L., Livingston, G.K., Potter, R.H., Christen, A.G., McDonald, J.L., Bolton, J.W.: Assessment of salivary cotinine levels in college students using smokeless tobacco. BioI. Monitoring 1 :53-59, 1991.

Livingston, G.K., Witt, K.S., Gandhi, O.P., Chatterjee, I., Roti Roti, 1.L.: The reproductive integrity of mammalian cells exposed to power frequency electromagnetic fields. Env. Molec. Mutagenesis 17:49-58, 1991.

Livingston, G.K., Reed, R.N., Olson, B., Lockey, J.E.: Induction of nuclear aberrations by smokeless tobacco in epithelial cells of human oral mucosa. Env. Molec. Mutagenesis 15:136- 144, 1990.

Lockey, J.E., Kelly, C.R., Cannon, G.W., Colby, T.V., Aldrich, V., Livingston, G.K.: Progressive systemic sclerosis associated with exposure to trichloroethylene. J. Occ. Med. 29:493-496, 1987.

Livingston, G.K., Lockey, J.E., Witt, K.S., Rogers, S.W.: An unstable giant satellite associated with chromosomes 21 and 22 in the same individual. Am. J. Human Genet. 37:553-560, 1985.

Elstner, C.L., Carey, J.C., Livingston, G.K., Moeschler, 1., Lubinsky, M.: Further delineation of the lOp deletion syndrome. Pediatrics 73 :670-675, 1984.

Lundberg, M.S., Livingston, G.K.: Sister-chromatid exchange frequency in lymphocytes of mothers and their newborn infants. Mutat. Res. 121:241-246, 1983.

Livingston, G.K., Cannon, L., Bishop, T., Johnson, P., Fineman, R.M.: Sister-chromatid exchange: variation by age, sex, smoking, and breast cancer. Cancer Genet. Cytogenet. 9:289- 299, 1983.

Miner, J .K., Rom, W.N., Livingston, G.K., Lyon, J .L.: Lymphocyte sister-chromatid exchange (SCE) frequency in coke oven workers. J. Occ. Med. 25:30-33, 1983.

Livingston, G.K., Fineman, R.M.: Correlation of human lymphocyte SCE frequency with smoking history. Mutat. Res. 119:59-64, 1983.

Rom, W.N., Livingston, G.K., Casey, K.R., Wood, S.K., Chiu, G.L., Egger, MJ., Jerominski, L.: Sister-chromatid exchange frequency in asbestos workers. JNCI 70:45-48, 1983.

Lundberg, M.S., Jerominski, L., Livingston, G.K., Kochenour, N.K., Lee, T.G., Fineman, R.M. Failure to demonstrate an effect of in vivo diagnostic ultrasound on sister-chromatid exchange frequency in amniotic fluid cells. Am. J. Med. Genet. 11 :31-35, 1982.

Nelson, J.A., Livingston, G.K., Moon, R.G.: Mutagenic evaluation of radiographic contrast media. Investigative Radiology 17: 183-185, 1982.

McRee, D.I., Livingston, G.K., MacNichols, G.: Incidence of sister-chromatid exchange in bone marrow cells of the mouse following microwave exposure. Rad. Res. 85:340-348, 1981.

Livingston, G.K., Rom, W.N., Morris, M.V.: Asbestos-induced sister-chromatid exchange in cultured Chinese hamster fibroblasts. Env. Pathol. Toxicol. 4:373-382, 1980.

Livingston, G.K.: Thermometry and dosimetry of heat with specific reference to the liquid crystal optical fiber temperature probe. Rad. Env. Biophys. 17:233-243, 1980.

Livingston, G.K., Dethlefsen, L.A.: Effects of hyperthermia and x-irradiation on sister-chromatid exchange frequency in Chinese Hamster Ovary (CHO) cells. Radiation Res. 77:512-520, 1979.

Livingston, G.K., Johnson C.C., Dethlefsen, L.A.: Comparative effects of water-bath and microwave-induced hyperthermia on survival of Chinese Hamster Ovary (CHO) cells. Radio Sci. 14:117-123,1979.

Book Chapters

Livingston, G.K.: Environmental Mutagenesis. In: Rom, W.N.: Environmental and Occupational Medicine. Little, Brown and Co., Boston, 1992, pp. 125-134.

Livingston, G.K.: Overview of specific chromosomal tests: micronucleus, heritable effects, dominant lethal, heritable translocation, and specific locus. In: Lockey, J.E., Lemasters, G.K., Keye, W.R.: Reproduction: The New Frontier in occupational and Environmental Health Research, Progress in Clinical and Biological Research. New York: Alan R. Liss 160:417-427, 1984.

Archer, V.E., Livingston, G.K.: Environmental carcinogenesis and mutagenesis. In: Rom W.M., ed. Environmental and occupational Medicine. Boston: Little, Brown and Company, 1983, pp. 63-74.

Livingston, G.K.: Statement on the use of toxic chemicals at Hill Air Force Base, Utah. Hearings before the Subcommittee on Investigations of the Committee on Post Office and Civil Service, House of Representatives, 96th Congress Serial No. 96-28, pp. 49-63, April 1979.