Research Project Description
Application of Computational Chemistry to Predictive Toxicity Modeling
Research Participation Program
Office of Research and Development
National Health and Environmental Effects Research Laboratory
U.S. Environmental Protection Agency
Gulf Breeze, FL
A postdoctoral research project training opportunity is currently available at the U.S. Environmental Protection Agency (EPA) National Health and Environmental Effects Research Laboratory (NHEERL) in Gulf Breeze, Florida. This appointment will be served in the Gulf Ecology Division (GED).
This research project aims to develop and apply state of the science computational chemistry methods to the development of predictive toxicity models. The selected participant will address the problem of how to improve the prediction of chemical toxicity using physical and chemical information. More specifically, s/he will focus on how computational chemistry can be used in developing improved predictive toxicity and mode of action models.
Joining a team of researchers focused on this problem, the selected participant may be involved in the following activities:
- Using chemical attribute information and theoretical chemistry approaches to determine the physical-chemical descriptors with the greatest association with chemical mode of action and toxicity
- Conducting research on how computational chemistry approaches can be used in quantitative structure activity relationship modeling
- Quantifying the uncertainty in physical chemical descriptor predictions of mode of action and toxicity.
The research participant will be mentored by a senior scientist at GED and learn to develop approaches for predictive mode of action and toxicity model development. S/he will have latitude in exercising independent initiative and judgment in the research commensurate with the level of training. EPA will review completed papers for adherence to NCEA principles and policies, quality, and soundness of scientific conclusions.
Specific learning opportunities may include:
- State of the science mode of action assignment methodologies
- Structure activity modeling approaches
- Application of computational and theoretical chemistry approaches to predictive model development
This research opportunity will provide the research participant exposure to how computational chemistry can be used in addressing research problems in predictive toxicity model development. Professional development opportunities could also include presenting work at scientific meetings, authoring publications, and collaborating with external (non-EPA) scientists and engineers.
Applicants must have received a doctoral degree in biochemistry, chemistry, mathematics or a closely related field within five years of the desired starting date, or completion of all requirements for the degree should be expected prior to the starting date.
The program is open to all qualified individuals without regard to race, sex, religion, color, age, physical or mental disability, national origin, or status as a Vietnam era or disabled veteran. U.S. citizenship or lawful permanent resident status is preferred (but can also hold an appropriate visa status, however, an H1B visa is not appropriate).
The appointment is full-time for one year and may be renewed for up to two additional years upon recommendation of EPA and subject to availability of funds. The participant will receive a monthly stipend. The participant must show proof of health and medical insurance. The participant does not become an EPA employee.
Funding may be made available to reimburse a research participant's travel expenses to present the results of his or her research at scientific conferences. No funding will be made available to cover travel costs for interviews, relocation costs, costs of tuition or school fees, or a participant's health insurance.
The contact person for this project is Mace Barron. He can be contacted at email@example.com.
How to Apply:
An application can be found at http://orise.orau.gov/epa/applicants/application.htm. Please reference Project # EPA-ORD/NHEERL-GED-2013-01 when calling or writing for information.