Supplementary

Acronym List

Acronym Description
AMES Ames Laboratory
AMWTP Advanced Mixed Waste Treatment Project
ANL Argonne National Laboratory
BAL Bronchoalveolar Lavage
BAWR Beryllium-Associated Worker Registry
Be Beryllium
BeLPT Beryllium Lymphocyte Proliferation Test
BeS Beryllium Sensitization or Beryllium-Sensitized
BNL Brookhaven National Laboratory
CBD Chronic Beryllium Disease
CBDPP Chronic Beryllium Disease Prevention Program
CFR Code of Federal Regulations
CY Calendar Year
DOD U.S. Department of Defense
DOE U.S. Department of Energy
DOE-ORO U.S. Department of Energy - Oak Ridge Office
DOL U.S. Department of Labor
EEOICPA Energy Employees Occupational Illness Compensation Program Act
ETTP East Tennessee Technology Park
EX Arithmetic Mean
F Percent Exceeding 0.2 µg/m3
Fermi Fermi National Accelerator Laboratory
HAN Hanford Site
INL Idaho National Laboratory
KAPL Knolls Atomic Power Laboratory
LANL Los Alamos National Laboratory
LBNL Lawrence Berkeley National Laboratory
LLNL Lawrence Livermore National Laboratory
LLNL BU Lawrence Livermore National Laboratory Boston University (subcontractor) 
LLNL CHES Lawrence Livermore National Laboratory Clean Harbors Environmental Services (subcontractor) 
LLNL ENVC Lawrence Livermore National Laboratory Envirocon, Inc. (subcontractor)
NA Not Applicable
NETL National Energy Technology Laboratory
NNSA DOE National Nuclear Security Administration
NNSS Nevada National Security Site
NSC National Security Campus
NSPS National Strategic Protective Services, LLC for ETTP and ORNL
OIG DOE Office of Inspector General
ORNL Oak Ridge National Laboratory
ORISE Oak Ridge Institute for Science and Education
OSHA DOL Occupational Safety and Health Administration
PADUCAH Paducah Site
PEL Personal Exposure Limit
PNNL Pacific Northwest National Laboratory
PTX Pantex Plant
Respirator APF Respirator Assigned Protection Factor
RF Rocky Flats Closure Project
SLAC SLAC National Accelerator Laboratory
SNL Sandia National Laboratories
SOMD Site Occupational Medical Director
SRS Savannah River Site
SWPA Southwestern Power Administration
TWA Time Weighted Average
µg/m3 Micrograms per Cubic Meter
UTL Upper Tolerance Limit
WSI Wackenhut Security Services, Inc. for ETTP, ORNL, and Y-12
Y-12 Y-12 National Security Complex
Y-12 ANS Y-12 National Security Complex Atkins Nuclear Secured (subcontractor)
Y-12 NRE Y-12 National Security Complex Navarro Research and Engineering (subcontractor) 
Y-12 URS Y-12 National Security Complex URS Corporation (subcontractor)

Calculations

Beryllium Sensitization Algorithm (current until revisions to 10 CFR 850 are passed): An employee is considered sensitized if any one of the following clinical criteria and incidence rules for the case definition of beryllium sensitizations is met. Often, an employee’s data will satisfy multiple criteria, and their date of sensitization is calculated as the earliest date any one of these is met.

  • 2 Positive or Abnormal BELPT results (based on 2 separate blood draws).
  • 1 Positive or Abnormal plus 2 (or more) Borderline BELPT results.
  • A Positive or Abnormal bronchoalveolar lavage (BAL) result.
  • A CBD Evaluation with a finding of sensitization but no chronic beryllium disease (CBD).

Exposure Monitoring Statistics: These calculations are based on the methods described in the Statistical Methods and Software for the Analysis of Occupational Exposure Data with Non-Detectable Values. Due to the limitations in laboratory analytic methods approaching nano- scales much of the airborne exposure monitoring data are subject to left censoring with a measurement below the detectable limit. The methods applied estimate non-detectable levels using maximum likelihoods for randomly left censored lognormal data with alternative non-parametric methods applied when the lognormal distribution is in doubt due to small sample sizes. For further details: https://www.csm.ornl.gov/esh/aoed/ORNLTM2005-52.pdf

Pearson Product-Moment Correlation Coefficient: This monitors the dose response represented by the BAWR data, and is calculated by site with the percent exceeding the action level and the percent beryllium sensitized or diagnosed with CBD. For further details: https://support.microsoft.com/en-us/office/pearson-function-0c3e30fc-e5af-49c4-808a-3ef66e034c18 

References and Resources

American Journal of Industrial Medicine, Clinical and laboratory factors contributing to uninterpretable beryllium lymphocyte proliferation tests (BeLPT), Derek Smith, et. al., March 2018. Abstract:  https://pubmed.ncbi.nlm.nih.gov/29574954

American Journal of Public Health, Illness Absences Among Beryllium Sensitized Workers, Janice Watkins, et. al., September 2014. Abstract: https://ajph.aphapublications.org/doi/abs/10.2105/AJPH.2014.302132

Beryllium-Associated Worker Registry 2017 Annual Report, Department of Energy, Office of the Associate Under Secretary for Environment, Health, Safety and Security. https://www.energy.gov/sites/prod/files/2019/05/f62/2017_Annual_BAWR_Report_Final.pdf

Chronic Beryllium Disease Prevention Program, 10 C.F.R. § 850 (1999). https://www.govinfo.gov/app/details/FR-1999-12-08/99-31181

Chronic Beryllium Disease Prevention Program, 10 C.F.R. § 850 (2012). https://www.govinfo.gov/app/details/CFR-2012-title10-vol4/CFR-2012-title10-vol4-part850

Department of Energy Technical Specification 1142, Beryllium Lymphocyte Proliferation Testing (BeLPT). DOE-SPEC-1142-2019. https://www.standards.doe.gov/standards-documents/1100/1142-dspec-2019

Department of Energy Technical Standard 1187, Beryllium-Associated Worker Registry Data Collection and Management Guidance.  DOE-STD-1187-2019. https://www.standards.doe.gov/standards-documents/1100/1187-astd-2019

Department of Labor Occupational Safety and Health Administration, Beryllium - Overview. https://www.osha.gov/beryllium

Department of Labor Occupational Safety and Health Administration, OSHA’s Rulemaking to Protect Workers from Beryllium Exposure. https://www.osha.gov/beryllium/rulemaking

Notice of Proposed Rulemaking 10 CRR Part 850, Federal Register, June 2016. https://www.gpo.gov/fdsys/pkg/FR-2016-06-07/pdf/2016-12547.pdf

Notice of Proposed Rulemaking, Chronic Beryllium Disease Prevention Program, 10 CFR 850, page 36748. https://www.gpo.gov/fdsys/pkg/FR-2016-06-07/pdf/2016-12547.pdf

Occupational and Environmental Medicine, Exposure and genetics increase risk of beryllium sensitisation and chronic beryllium disease in the nuclear weapons industry, Michael Van Dyke, et. al., November 2011. Abstract:  https://pubmed.ncbi.nlm.nih.gov/21460389

PEARSON function. https://support.microsoft.com/en-us/office/pearson-function-0c3e30fc-e5af-49c4-808a-3ef66e034c18

STAND:  Statistical Analysis of Non-Detects. https://cran.r-project.org/web/packages/STAND/index.html

Statistical Methods and Software for the Analysis of Occupational Exposure Data with Non-Detectable Values, Frome EL and Wambach PF, ORNL/TM-2005/52. https://www.csm.ornl.gov/esh/aoed/ORNLTM2005-52.pdf

The R Project for Statistical Computing. https://www.r-project.org  

Worker Safety and Health Program, 10 C.F.R. § 851.10 (2006). https://www.govinfo.gov/app/details/CFR-2020-title10-vol4/CFR-2020-title10-vol4-sec851-10