Jan 22, 2019

Since the Department of Energy (DOE) published the DOE Beryllium Rule in 1999, DOE sites have been required to measure beryllium levels for worker protection and for release of materials from beryllium-controlled areas. This rule was established to accomplish three goals: 1) reduce the number of workers currently exposed to beryllium, 2) minimize exposures and the potential for exposure, 3) and establish medical surveillance requirements for early detection of disease.

Did the rule work to protect workers? While its impact has been evaluated through observational reports, with decreases in exposure and reported cases of beryllium sensitization (BeS), there have been no published studies assessing whether exposure reduction activities have had a statistically significant impact in the prevention of BeS… until now.

ORISE examined the incidence of BeS in a cohort of 6,915 workers employed at a single DOE nuclear site with nearly 29,000 beryllium lymphocyte proliferation test (BeLPT) results obtained 1994 to 2018. The BeLPT is a blood test that measures beryllium sensitization, which is considered an allergic reaction to beryllium and a potential precursor to Chronic Beryllium Disease.

Workers were classified as beryllium sensitized when they met one of the following conditions: two abnormal blood BeLPT results, one abnormal and one borderline blood BeLPT result, three borderline blood BeLPT results, or one abnormal lung lavage BeLPT result, where cells and fluid from the lungs are analyzed.

Results of the study indicated an overall decrease in exposure and BeS incidence rates among the cohort, with some outlier data based on site cleanup activities involving beryllium. These findings provide support that the DOE Beryllium Rule helps avoid additional BeS cases. Future research will more precisely assess the relationship between beryllium exposure levels and beryllium incidence over time to inform possible predictions in estimating the burden of disease that could be reduced with enactment of new proposed exposure rules.

For more information:

ORISE Beryllium Testing Laboratory
Phone: 865.576.3115



Toll-Free Numbers for Workers
Beryllium Vendor Screening Program: 1.866.219.3442
Beryllium Medical Surveillance Program: 1.866.219.3442


Media Contacts

Pam Bonee
Director, Communications
Office: 865.576.3146
Phone: 865.603.5142

Wendy West
Manager, Communications
Office: 865.576.0028
Phone: 865.207.7953

The Oak Ridge Institute for Science and Education (ORISE) is a U.S. Department of Energy (DOE) asset that is dedicated to enabling critical scientific, research, and health initiatives of the department and its laboratory system by providing world class expertise in STEM workforce development, scientific and technical reviews, and the evaluation of radiation exposure and environmental contamination. 

ORISE is managed by ORAU, a 501(c)(3) nonprofit corporation and federal contractor, for DOE’s Office of Science. The single largest supporter of basic research in the physical sciences in the United States, the Office of Science is working to address some of the most pressing challenges of our time. For more information, please visit science.energy.gov.