Published Research Research addresses medical aspects of radiation incidents

The expertise at the Radiation Emergency Assistance Center Training Site (REAC/TS) extends beyond a commitment to educate medical providers, health physicists, and other emergency response personnel about the medical management of radiation injuries. REAC/TS staff regularly contribute to the greater medical community through collaborations with other scientists to publish scholarly articles that address the medical aspects of radiation incidents. A sampling of recent publications is listed below.

• Royba E, Repin M, Balajee AS, Shuryak I, Pampou S, Karan Ch, Wang Y-F, Lemus OD, Obaid R, Deoli N, Wuu C-S, Brenner DJ, Garty G. (2023, January). Validation of a High-Throughput Dicentric Chromosome Assay Using Complex Radiation Exposures. Radiation Research: 199, 1-16.
• Meador JA, Morris RJ, Balajee AS (2022, December). Ionizing Radiation-Induced DNA Damage Response in Primary Melanocytes and Keratinocytes of Human Skin. Journal of Cytogenetic and Genome Research: 162(4), 188-200.
• Paccosi, Elena, Balajee, Adayabalam S., Proietti-De-Santis, Luca (2022, July). A matter of delicate balance: Loss and gain of Cockayne syndrome proteins in premature aging and cancer - PMC (nih.gov). Frontiers in Aging: A section on Interventions in Aging.
• Escalona, Maria B., Ryan, Terri L., Balajee, Adayabalam, S. (2022, July). Current developments in biodosimetry tools for radiological/nuclear mass casualty incidents. Environmental Advances special issue: Global Radiation Emergency Preparedness and Response: Public Health Perspective.
• C.J. Iddins, J.E. Davis (2022, May 11). Internal contamination cases: The REAC/TS experience. Environmental Advances special issue: Global Radiation Emergency Preparedness and Response: Public Health Perspective.
• C.J. Iddins, J.E. Davis (2022, May 11). Recognition of radiation-induced injuries as sentinel indicators of uncontrolled radioactive material. Environmental Advances special issue: Global Radiation Emergency Preparedness and Response: Public Health Perspective. Epub ahead of print.
• J.A. Meador, A.S. Balajee (2022, April 18). Analysis of ionizing radiation induced DNA damage response in human adult stem cells and differentiated neurons. Published in Mutation Research - Genetic Toxicology and Environmental Mutagenesis.
• S. Sholom, S.W.S. McKeever, M.B. Escalona, T.L. Ryan, A.S. Balajee (2022, February). A comparative validation of biodosimetry and physical dosimetry techniques for possible triage applications in emergency dosimetry. Journal of Radiation Protection. Accepted manuscript.
• E. Gregoire, J. F. Barquinero, G. Gruel, M. Benadjaoud, J.S. Martinez, C. Beinke, A. Balajee, P. Beukes, W.F. Blakely, I. Dominguez, P. N. Duy, O. M. Gil, I. Güçlü, K. Guogyte, S.P. Hadjidekova, V. Hadjidekova, P. Hande, S. Jang, K. Lumniczky, R. Meschini, M. Milic, A. Montoro, J. Moquet, M. Moreno, F.N. Norton, U. Oestreicher, J. Pajic, L. Sabatier, S. Sommer, A. Testa, G. Terzoudi, M. Valente, P. Venkatachalam, A. Vral, R.C. Wilkins, A. Wojcik, D. Zafiropoulos, & U. Kulka (2021). RENEB Inter-Laboratory comparison 2017: limits and pitfalls of ILCs, International Journal of Radiation Biology, 97:7, 888-905.
• C.J. Iddins, A.L. DiCarlo, M.D. Ervin, E. Herrera-Reyes, R. Goans (2021, September 6). Cutaneous and local radiation injuries. Journal of Radiological Protection. Epub.
• M. Keenan, T. Behrens, S. Bravenec, J. Davis, A. Bowen, R. Goans, & C. Iddins (2021, September). Americium Inhalational Exposure with Successful Chelation Therapy. Disaster Medicine and Public Health Preparedness, 1-5.
• A.S. Balajee, G.K. Livingston, M.B. Escalona, T.L. Ryan, R.E. Goans, C.J. Iddins (2021, July 7). Cytogenetic follow-up studies on humans after internal and external exposures to ionizing radiation. Journal of Radiological Protection. Epub ahead of print. PMID: 34233319
• N.E. Martinez, D.W. Jokisch, L.T. Dauer, K.F. Eckerman, R.E. Goans, J.D. Brockman, S.Y. Tolmachev, M. Avtandilashvili, M.T. Mumma, J.D. Boice, & R.W. Leggett (2021, April 26). Radium dial workers: back to the future. International Journal of Radiation Biology. Epub ahead of print. PMID: 33900890
• R.E. Goans, C.J. Iddins (2021, April). The neutrophil to lymphocyte ratio as a triage tool in criticality accidents. Health Physics 120(4): 410-416.
• Q. Tan, K. Niu, Y. Zhu, Z. Chen, Y. Li, M. Li, D. Wei, A.S. Balajee, H. Fang, Y. Zhao (2021, March). RNF8 ubiquitinates RecQL4 and promotes its dissociation from DNA double strand breaks. Oncogenesis, 10(3): 24.
• G. George, J.I. Hayes, C.N. Collins, J. Davis, L. Yu, Y. Lin, J. Wen, D. Ila, Z. Luo (2021, March). Size- and concentration-dependent Eu2+/Eu3+ mixed luminescent characteristics of rare-earth-doped CaF2 nanoparticles and their monolithic epoxy nanocomposites. Journal of Alloys and Compounds, 857: 157591.
• A.S. Balajee, Valeria Hadjidekova (2021, January-February). Retrospective cytogenetic analysis of unstable and stable chromosome aberrations in the victims of radiation accident in Bulgaria. Mutation Research/Genetic Toxicology and Environmental Mutagenesis, 861–862: 503295
• R.E. Goans (2021, January). Power function retention of radionuclides in a wound. Health Physics, 120(1): 94-97.
• J.T. Sanders, T.F. Freeman, Y. Xu, R. Golloshi, M.A. Stallard, A.M. Hill, R. San Martin, A.S. Balajee, R.P. McCord (2020, December). Radiation-induced DNA damage and repair effects on 3D genome organization. Nature Communications, 11(1): 6178.
• A. Bowen, T.G. Veenema, S. Schneider-Firestone, C. Iddins, D. Boyce, J. Davis, C. Thornton (2020, September). Exploring National Nursing Readiness for a Radiological or Nuclear Incident. Journal of Emergency Nursing, 46(5): 600-610; 2020.
• B.P. Murray, E. Kim, S.A. Ralston, T.P. Moran, C. Iddins, Z. Kazzi (2020, January). Radiation emergency readiness among US medical toxicologists: A survey. Disaster Medicine and Public Health Preparedness, 1-6.
• G.K. Livingston, T.L. Ryan, T.L. Smith, M.B. Escalona, A.E. Foster, A.S. Balajee (2019, December). Detection of simple, complex and clonal chromosome translocations induced by internal radioiodine exposure: A cytogenetic follow-up case study after 25 years. Cytogenetic and Genome Research, 159(4):169-181.
• T.L. Ryan, M.B. Escalona, T.L. Smith, J. Albanese, C.J. Iddins, A.S. Balajee (2019, November). Optimization and validation of automated dicentric chromosome analysis for radiological/nuclear triage applications. Mutation Research/Genetic Toxicology and Environmental Mutagenesis, 847: 503087.
• K. Niu, H. Fang, Z. Chen, Y. Zhu, Q. Tan, D. Wei, Y. Li, A.S. Balajee, Y. Zhao (2019, August). USP33 deubiquitinates PRKN/parkin and antagonizes its role in mitophagy. Autophagy, 26: 1-11.
• R.E. Goans, R.E. Toohey, C.J. Iddins, N. Dainiak, S.L. McComish, S.Y. Tolmachey (2019, August). The Pseudo Pelger-Huët Cell as a Retrospective Dosimeter: Analysis of a Radium Dial Painter Cohort. Health Physics, 117(2): 143-148.
• T. Smith, M. Escalona, T. Ryan, G.K. Livingston, J. S. Tyler and A.S. Balajee (2019, May). Extension of lymphocyte viability for radiation biodosimetry: Potential implications for radiological/nuclear mass casualty incidents. Journal of Cell Biochemistry, 120(5): 8619-8629.
• T.L. Ryan, A.G. Pantelias, G.I. Terzoudi, G.E. Pantelias, A.S. Balajee (2019, May). Use of human lymphocyte G0 PCCs to detect intra- and inter-chromosomal aberrations for early radiation biodosimetry and retrospective assessment of radiation-induced effects. PLoS ONE, 14(5): e0216081.
• J. Davis (2019, April). Radiation doses to practitioners caring for victims of a radiological accident. Radiation Environment and Medicine, 8(2): 39-44.
• Viswanathan, K. Kanagaraj, V. Raavi, S. Dhanasekaran, V. Panicker, R. Krishnamoorthy, A. Balajee, and V. Perumal (2019, April). Does proliferation capacity of lymphocytes depend on human blood type? Journal of Cellular Biochemistry, 120(4): 5722-5728.
• A.S. Balajee, M. Escalona, C. Iddins, I. Shuryak, G. Livingston, D. Hanlon, N. Dainiak (2019, February). Development of electronic training and telescoring tools to increase the surge capability of dicentric chromosome scorers for radiological/nuclear mass casualty incidents. Applied Radiation and Isotopes, 144: 111-117.
• N. Dainiak, J. Albanese, M. Kaushik, A.S. Balajee, A. Romanyukha, T.J. Sharp, W.F. Blakely. (2019, February). Concepts of Operations for a US Dosimetry and Biodosimetry Network. Radiation Protection Dosimetry, ncy294.
• J.E. Davis, S A. Dewji, E. Abelquist, N. Hertel (2019, January). Synopsis of the Oak Ridge Radiation Protection Research Needs Workshop. Health Physics, 116(1): 69-80.
• A.S. Balajee and M.P. Hande (2018, December). History and evolution of cytogenetic techniques: Current and future applications in basic and clinical research. Mutation Research/Genetic Toxicology and Environmental Mutagenesis, 836 (Part A): 3-12.
• G. George, M.D. Simpson, B.R. Gautum, D. Fang, J. Oeng, J. Wen, J.E. Davis, D. Ila, and Z. Luo (2018, November). Luminescence characteristics of rare-earth-doped barium hexafluorogermanate BaGeF₆nanowires: fast subnanosecond decay time and high sensitivity in H₂O₂detection. RSC Advances, 69: 39296-39306.
• A.S. Balajee (2018, October). Applications of fluorescence in situ hybridization in radiation cytogenetic biodosimetry and population monitoring. OBM Genetics, 2: 1-35.
• A.S. Balajee, T. Smith, T. Ryan, M. Escalona, N. Dainiak (2018, September). Development of a miniaturized version of dicentric chromosome assay tool for radiological triage. Radiation Protection Dosimetry, 182(1): 139-145.
• H. Fang, K. Niu, D. Mo, Y. Zhu, Q. Tan, D. Wei, Y. Li, Z. Chen, S. Yang, A.S. Balajee, Y. Zhao (2018, September). RecQL4-Aurora B kinase axis is essential for cellular proliferation, cell cycle progression, and mitotic integrity. Oncogenesis, 7(9): 68.
• M. Cicero, T. Whitfill, B. Walsh, M. Carmen-Diaz, G. Arteaga, D. Scherzer, S. Goldberg, M. Madhok, A. Bowen, G. Paesano, M. Redlener (2018, August). Correlation Between Paramedic Disaster Triage Accuracy in Screen-Based Simulations and Immersive Situations. Prehospital Emergency Care, 23(1): 83-89.
• A.S. Balajee, J.T. Sanders, R. Golloshi, I. Shuryak, R.P. McCord, N. Dainiak (2018, July). Investigation of Spatial Organization of Chromosome Territories in Chromosome Exchange Aberrations After Ionizing Radiation Exposure. Health Physics, 115(1): 77-89.
• G. George, S.L. Jackson, Z.R. Mobley, B.R. Gautam, D. Fang, J. Peng, D. Luo, J. Wen, J.E. Davis, D. Ila, and Z. Luo (2018, June). Fast luminescence from rare-earth-codoped BaSiF₆nanowires with high aspect ratios. Journal of Materials Chemistry C, 27: 7285-7294.
• R.P. McCord and A.S. Balajee (2018, June). 3D Genome Organization Influences the Chromosome Translocation Pattern. Advances in Experimental Medicine and Biology, Book Series, 1044: 113-133.
• G.K. Livingston, J.H. Petajan, A.S. Balajee (2018, May). Chromosome translocation in a female with a history of fetal loss and chronic progressive multiple sclerosis. Chromosome Science, 20 (1-4): 3-8.
• M. Cicero, T. Whitfill, B. Walsh, M. Carmen-Diaz, G. Arteaga, D. Scherzer, S. Goldberg, M. Madhok, A. Bowen, G. Paesano, M. Redlener, K. Munjal, D. Kessler, M. Auerbach (2018, April). 60 Seconds to Survival: A Multisite Study of a Screen-based Simulation to Improve Prehospital Providers Disaster Triage Skills. Academic Emergency Medicine Education and Training, 2(2): 100-106.
• D. Mo, Y. Zhao and A.S. Balajee (2018, January). Human RecQL4 helicase plays multifaceted roles in the genomic stability of normal and cancer cells. Cancer Letters, 413: 1-10.
• G.K. Livingston, M. Escalona, A. Foster, A.S. Balajee (2018, January). Persistent in vivo cytogenetic effects of radioiodine therapy: a 21-year follow-up study using multicolor FISH. Journal of Radiation Research, 59(1): 10-17.
• M. Cicero, T. Whitfill, K. Munjal, M. Madhok, M. Diaz, D. Schwerzer, B. Walsh, A. Bowen, M. Redlener, S. Goldberg, N. Symons, J. Burkett, J. Santos, D. Kessler, R. Barnicle, G. Paesano, M. Auerbach (2017, Spring). 60 Seconds to Survival: A Randomized Controlled Trial of a Disaster Triage Video Game For Prehospital Care Providers. American Journal of Disaster Medicine 12(2): 75-83.