Radiation Countermeasures
Radiation Emergency Assistance Center/Training Site (REAC/TS) professionals maintain a registry of clinical information and provide expertise to practitioners worldwide on the use of calcium-diethylenetriaminepentaacetic acid (DTPA) and zinc-diethylenetriaminepentaacetic acid (DTPA) and Radiogardase Prussian Blue (Radiogardase™) to treat radiation poisoning.
- Calcium-DTPA (.PDF, 416 KB) and Zinc-DTPA (.PDF, 345 KB) are injectable chelating agents used to enhance the excretion of plutonium and other transuranics from the body.
- Radiogardase™ Prussian Blue (.PDF, 420 KB) binds to radiocesium and thallium and enhances their excretion from the body.
Package inserts are available for radiation treatment pharmaceuticals calcium-DTPA, zinc-DTPA, and Radiogardase (Prussian Blue).
- Calcium-DTPA package insert (.PDF, 416 KB)
- Zinc-DTPA package insert (.PDF, 345 KB)
- Radiogardase (Prussian Blue) package insert (.PDF, 420 KB)
Read more about DTPA and Prussian Blue on the Centers for Disease Control and Prevention website.
How to obtain DTPA and Prussian Blue (US/International)
REAC/TS has no financial or other interest with the following companies. This is for informational purposes only and is subject to change. We encourage anyone needing these medications to contact these companies prior to an event.
United States (Individual patients, by prescription only):
Radiogardase cannot be sold directly to physicians, but only via patient prescription placed with McGuff Compounding Pharmacy at 1-877-444-1133, fax 1-877-444-1155. Institutional and government agencies must begin the order process by first contacting Heyltex McGuff Company is a contracted third party logistics provider for Heyltex.
Prussian Blue (Radiogardase)
McGuff Compounding Pharmacy
2921 W Macarthur Blvd #142
Santa Ana, CA 92704
Phone: 1-877-444-1133 (8 a.m. to 5:30 p.m. PT)
Fax: 1-877-444-1155
Prussian Blue for stockpile
Heyltex Corporation
925 South Mason Rd., PMB #242
Katy, Texas 77450
Phone: 1-855-439-5839 (1-855-HEYLTEX)
Fax: 1-855-937-9377
Cell: 1-713-305-0873
Lily Heyl: lily@heyltex.com
Available: 4-12 weeks
Ca and Zn DTPA
Golden State Medical Supply
5187 Camino Ruiz
Camarillo, California 93012
Phone: 1-805-477-9866
8:30 a.m. to 5:30 p.m. PT
Website
International:
Prussian Blue/Ca and Zn DTPA
Heyl Chemisch-pharmazeutische Fabrik GmbH & Co. KG
Kurfürstendamm 178 – 179
10707 Berlin | Deutschland
Phone: +49 30 816 96 – 0
Fax: +49 30 817 40 49
Email: info@heyl-berlin.de
Product information
Nplate® (Romiplostim) approved for use in Hematopoietic Syndrome of Acute Radiation Syndrome (HS-ARS)
The National Institute of Allergy and Infectious Diseases (NIAID)/National Institute of Health’s (NIH) Radiation and Nuclear Countermeasures Program (RNCP) announced on January 28, 2021, that the FDA approved application by Amgen for Nplate® (Romiplostim) to add the following indication to the package insert:
“Patients with Hematopoietic Syndrome of Acute Radiation Syndrome (HS-ARS): Nplate is indicated to increase survival in adults and pediatric patients (including term neonates) acutely exposed to myelosuppressive doses of radiation.”
The RNCP, along with the Division of Allergy, Immunology, and Transplantation (DAIT) Office of Regulatory Affairs and Clinical Research Operations Program, is tremendously proud to have been a part of the team involved in this regulatory approval. In the case of a radiological or nuclear public health emergency, many thousands of people could experience severe injuries from radiation exposure, resulting in immunosuppression and infection, hemorrhage, major morbidities, and even death.
Video Spotlight
What is DTPA?
DTPA injectable chelating agents used to enhance the excretion of plutonium and other transuranics from the body. DTPA comes in two forms—calcium (Ca-DTPA) and zinc (Zn-DTPA)—both of which bind to radioactive plutonium, americium, and curium. Watch the video to learn more about DTPA and its use in radiation exposure treatment.
What is Prussian Blue?
Prussian Blue is an ingestable capsule that helps remove radioactive cesium and thallium from the body. One of Prussian Blue's advantages is that it reduces amount of time the body is exposed to radiation. Watch the video to learn more about Prussian Blue (Radiogardase) and its use in the treatment of acute radiation exposure.